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Although testosterone levels normally evolve during puberty, deficient testosterone production after a β-hCG stimulation test becomes evident and hypergonadotropic hypogonadism with severe testicular atrophy and azoospermia in biopsied testes is clearly manifested in adulthood15,16). In this case, there was normal response in the plasma testosterone level after β-HCG stimulation performed at the age of 4.2 years, and this result only suggested that testis tissue was present. As testicular atrophy progresses with age, follow-up stimulation test performed during adolescence might show abnormal response as testicular atrophy progresses.
- We would like to highlight several issues, consideration of which could promote more rapid progress in the field.
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- There is limited evidence that women with musculoskeletal pain are more likely to be depressed than men.
- The inflammatory response to various triggering events involves plasma extravasation, chemotactic attraction of leukocytes, and, in turn, stimulated release of inflammatory cytokines and growth factors.
- The Ministry of Justice has previously said that offering accommodation in exchange for sex is inciting prostitution, an offence which can carry a sentence of up to seven years in jail.
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In 1927, the University of Chicago’s Professor of Physiologic Chemistry, Fred C. Koch, established easy access to a large source of bovine testicles – the Chicago stockyards – and recruited students willing to endure the tedious work of extracting their isolates. Female-to-male sex reversal in individuals with 46,XX is most frequently caused by the presence of SRY on one of the X chromosome resulting from a translocation between the X and Y chromosomes17). This translocation event occurs randomly during spermatogenesis in the affected individual’s father.
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In this era of translational science, an important goal for future research in this area is to generate information that will enhance pain treatment for both sexes. Despite the challenges of translational research, several opportunities that could be exploited to enhance translation have previously been suggested.118 For example, human laboratory pain models and genetic research could both serve as translational bridges between laboratory findings from nonhuman animals and clinical populations. For example, Mogil and colleagues284 successfully translated a novel sex-related genetic association (ie, the melanocortin-1-receptor gene, MC1R) with analgesic responses across species using experimental pain models in both mice and humans.
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DreamGF ensures that these features are available to users who are of legal age and adhere to the platform’s guidelines and terms of use. Moreover, gonadal steroids exert both organizational and activational effects, which refer to long-term developmental influences versus transient effects in adulthood, respectively. The impact of sex hormones on pain responses can be broadly dichotomized into peripheral versus central nervous system effects, which are discussed below. Kroner-Herwig and others231 assessed the distribution and characteristics of headache in German children aged 7 to 14 years using International Classification of Headache Disorders-II criteria to classify headaches into migraine or tension-type. They found that, similar to migraines, boys have an earlier onset to nonmigraine headache than girls. The prevalence of nonmigraine headache was similar for girls and boys of elementary school age years with increasing prevalence for girls during adolescence.
